Will you take the mRNA Vaccine Immediately When Available?

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Do you plan on taking either the Moderna or Pfizer mRNA vaccine immediately when available?

  • Yes

    Votes: 170 77.6%

  • No

    Votes: 49 22.4%
  • Total voters
    219
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turkeyjerky said:
Are ya’ll getting much info from your hospitals on the actual logistics of vaccinations? Doesn’t seem like the tightest ship here...
Click to expand...
we were promised some updates in the near future.

To be fair, only pfizer's vaccine has been EUA'd by the FDA. And that was like 2 days ago.
 
They tell us next week, and already sent out and an e-mail to see who wants to get it.

Interestingly they are telling those getting the vaccine to not work that day as they might get fever or flu-symptoms.
 
southerndoc said:
My main fire department gig (where I'm medical director) is getting their first shipment on Monday. Odd how it was just approved but we're getting it first business day. The second set of doses will arrive 21 days later.
Click to expand...

My friend's hospital got a shipment last night. It was sent right after the approval.
Everyone seems that they were preparing for it to definitely get approved so things moved pretty quickly. I'm sure a bunch of places are getting their stock today and tomorrow as well.
 
Have they tested this mRNA vaccine on people who have recovered from COVID and developed an antibody response already?

A concern would be that programming your body to make large amounts of viral antigen, which your body is already primed to fight could trigger an intense immune response and lead to serious illness.
 
GeneralVeers said:
Have they tested this mRNA vaccine on people who have recovered from COVID and developed an antibody response already?

A concern would be that programming your body to make large amounts of viral antigen, which your body is already primed to fight could trigger an intense immune response and lead to serious illness.
Click to expand...
I haven't read anything about this either way, with the COVID vaccine, yet. So I can't answer your question. I can't counter your good question, with a dumb question: If what you describe is likely, wouldn't we see that with noticeable amount people after getting flu shots, yearly? (Which I don't think we do, do we?)
 
GeneralVeers said:
Have they tested this mRNA vaccine on people who have recovered from COVID and developed an antibody response already?

A concern would be that programming your body to make large amounts of viral antigen, which your body is already primed to fight could trigger an intense immune response and lead to serious illness.
Click to expand...
Has that ever happened with a vaccine before?
 
GeneralVeers said:
Have they tested this mRNA vaccine on people who have recovered from COVID and developed an antibody response already?

A concern would be that programming your body to make large amounts of viral antigen, which your body is already primed to fight could trigger an intense immune response and lead to serious illness.
Click to expand...
Have we seen that in people who've had influenza then got the flu shot?
 
bravotwozero said:
Have we seen that in people who've had influenza then got the flu shot?
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Isn't this a different mechanism? With flu shot it's a small dose of extracellular antigen that's injected. With the mRNA vaccine your cells are actually producing the antigen. I'm just curious because I've not seen any discussion of this. All discussion of vaccinating healthcare works seems to assume that a low percentage or small percentage have had COVID when in reality it's 30-50% where I work.
 
AMEHigh said:
I don't work inpatient, so I'm low on the list, but my friends who do work inpatient have started getting emails about setting up appointments.

For those not wanting the Pfizer or Moderna vaccines. Will you be ok with getting the AstraZeneca or Johnson and Johnson vaccines?
Click to expand...
All of those use mRNA technology. The only company using standard vaccine tech that I know of is Novavax.
 
GeneralVeers said:
Isn't this a different mechanism? With flu shot it's a small dose of extracellular antigen that's injected. With the mRNA vaccine your cells are actually producing the antigen. I'm just curious because I've not head any discussion of this. All discussion of vaccinating healthcare works seems to assume that a low percentage or small percentage have had COVID when in reality it's 30-50% where I work.
Click to expand...
Yes, this is correct.

I still haven’t figured out why there was a mass rush to implement mRNA vaccines, which are groundbreaking tech, for the pandemic. Why did we change our method of vaccination all of the sudden?
 
Lawpy said:
Were there SARS or MERS vaccines?
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I’m not sure. the only mRNA vaccines I know of have been used for Ebola and Dengue.
If the mRNA vaccines work ok and are well-tolerated (I’m still not sold about well-tolerated) then it’s a game-changer for how we do therapeutics. Exciting times either way.
 
VA Hopeful Dr said:
Has that ever happened with a vaccine before?
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Spikebd said:
I’m not sure. the only mRNA vaccines I know of have been used for Ebola and Dengue.
If the mRNA vaccines work ok and are well-tolerated (I’m still not sold about well-tolerated) then it’s a game-changer for how we do therapeutics. Exciting times either way.
Click to expand...

Not a physician, but we learned this week that this is why we don't have an RSV vaccine. The vaccine (which was not mRNA), was producing worse cases of RSV in patients who had already had it because it was producing antibody dependent enhancement (ADE). This also happened with the dengue vaccine, which is mRNA. The professor emphasized that Sars-Cov-2 was a good candidate for this to happen with a vaccine, specifically stating that the fact that COVID-19 has been overall worse in older adults than in young people indicated that there might be antibodies present in older people from a different but similar coronavirus in the past (even decades ago) that younger people were never exposed to.

I'm not sure how much validity there is to his statement, and I don't yet have the medical knowledge to go digging for answers, but I thought it was interesting in light of the coming vaccines. I did find this article though:

www.nature.com

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies - Nature Microbiology

Mechanisms of antibody-dependent enhancement of disease and mitigation strategies for SARS-CoV-2 vaccines and therapies are discussed.
www.nature.com www.nature.com
 
I'm not that worried about tolerability in the COVID naïve patients, but one would hope they did their due diligence and tested it on recovered patients to make sure they don't get worse reactions. By the time the vaccine is available huge swathes of the population will have had COVID, and vaccinating all of them seems silly, and questionable.
 
GeneralVeers said:
I'm not that worried about tolerability in the COVID naïve patients, but one would hope they did their due diligence and tested it on recovered patients to make sure they don't get worse reactions. By the time the vaccine is available huge swathes of the population will have had COVID, and vaccinating all of them seems silly, and questionable.
Click to expand...
Is covid vaccination going to be an annual thing going forward? How long does the presumed protection from the mRNA vaccine last?
 
Dame_Maggie said:
Not a physician, but we learned this week that this is why we don't have an RSV vaccine. The vaccine (which was not mRNA), was producing worse cases of RSV in patients who had already had it because it was producing antibody dependent enhancement (ADE). This also happened with the dengue vaccine, which is mRNA. The professor emphasized that Sars-Cov-2 was a good candidate for this to happen with a vaccine, specifically stating that the fact that COVID-19 has been overall worse in older adults than in young people indicated that there might be antibodies present in older people from a different but similar coronavirus in the past (even decades ago) that younger people were never exposed to.

I'm not sure how much validity there is to his statement, and I don't yet have the medical knowledge to go digging for answers, but I thought it was interesting in light of the coming vaccines. I did find this article though:

www.nature.com

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies - Nature Microbiology

Mechanisms of antibody-dependent enhancement of disease and mitigation strategies for SARS-CoV-2 vaccines and therapies are discussed.
www.nature.com www.nature.com
Click to expand...
Interesting, so this seems to mean that people with some type of antibodies or cross-reactive antibodies to covid-19 might be worse off with a vaccine?
 
Spikebd said:
Interesting, so this seems to mean that people with some type of antibodies or cross-reactive antibodies to covid-19 might be worse off with a vaccine?
Click to expand...
That was my concern, based on my limited knowledge of how mRNA vaccines work. If the mRNA makes your cells pump out spike protein, would that trigger a greater, immune response if someone already has antibodies to COVID? Also, since the antibodies are already present, will that trigger an immune response against your own cells?
 
Spikebd said:
Is covid vaccination going to be an annual thing going forward? How long does the presumed protection from the mRNA vaccine last?
Click to expand...
It depends if the virus mutates and there are new strains every year like flu. Otherwise, it will probably mostly disappear at some point.
 
Spikebd said:
Yes, this is correct.

I still haven’t figured out why there was a mass rush to implement mRNA vaccines, which are groundbreaking tech, for the pandemic. Why did we change our method of vaccination all of the sudden?
Click to expand...

Because this was a once in a century pandemic and it’s the fastest way to produce a new vaccine? When 3k people are dying everyday despite interventions that have flattened the curve bit tanked the economy, weeks matter.

Spikebd said:
Interesting, so this seems to mean that people with some type of antibodies or cross-reactive antibodies to covid-19 might be worse off with a vaccine?
Click to expand...

No it means an immunology professor with limited clinical experience hypothesized that this may be the mechanism of more severe disease. The same hypothesis that has been applied to the (surprisingly) good outcomes amongst elderly infected with H1N1 in 2009 or the (unsurprisingly) good outcomes in children infected with SARS-CoV-2

I wouldn’t worry about reverse-immune enhancement with the mRNA vaccines because the antigenic exposure will be dosage-limited, rather than potentially continuously replicating
 
Spikebd said:
Interesting, so this seems to mean that people with some type of antibodies or cross-reactive antibodies to covid-19 might be worse off with a vaccine?
Click to expand...

I don’t have enough knowledge to give any sort of definitive opinion, I just though it was interesting that he pointed it out this week, and is definitely something I’ll be watching from the bottom of the vaccine priority list.

And this was clinical faculty, not an immunology PhD, for whatever that’s worth.
 
Honestly, I'm surprised you guys aren't bored with discussing COVID, at this point. I went hard for 6 months, but I now find it a big bore. I'm more focused on going all in, on a life long goal I will hopefully achieve within the next 3 months, God willing.
 
GeneralVeers said:
It depends if the virus mutates and there are new strains every year like flu. Otherwise, it will probably mostly disappear at some point.
Click to expand...
I'm assuming it ends up another endemic coronavirus that causes a cold but nothing worse once everyone has either had the vaccine or had the actual virus
 
Birdstrike said:
Honestly, I'm surprised you guys aren't bored with discussing COVID, at this point. I went hard for 6 months, but I now find it a big bore. I'm more focused on going all in, on a life long goal I will hopefully achieve within the next 3 months, God willing.
Click to expand...

Agree. People still talking about masks too. Snooze fest.

With that said I'll be getting my vaccination next week. Surprised at how on top of stuff my hospital has been surprisingly.
 
GeneralVeers said:
Have they tested this mRNA vaccine on people who have recovered from COVID and developed an antibody response already?

A concern would be that programming your body to make large amounts of viral antigen, which your body is already primed to fight could trigger an intense immune response and lead to serious illness.
Click to expand...

So I can only speak for the trial I'm in...
They didn't test us beforehand or anything to know if we had active covid or antibodies.
They didn't even test us the day of our vaccine to see if we had active covid.
They did take a nasal swab on my first appointment and said they'd run it only if I developed covid like symptoms within the week of getting the vaccine to see if I actually had covid or if my symptoms were vaccine side effect.
So presumably some of the people who got the vaccine could've had antibodies already. I have not read if they've actually published any data about that. So far most of the trials have pretty promising safety data from the dozens of thousands of people in the trials, but of course there are still questions.
 
Spikebd said:
All of those use mRNA technology. The only company using standard vaccine tech that I know of is Novavax.
Click to expand...

Sorry I guess my question wasn't clear.
I wasn't sure if people that are saying they won't get the vaccine in this poll have specific worries about pfizer or moderna and are open to other companies manufacturing the vaccine.
 
AMEHigh said:
My friend's hospital got a shipment last night. It was sent right after the approval.
Everyone seems that they were preparing for it to definitely get approved so things moved pretty quickly. I'm sure a bunch of places are getting their stock today and tomorrow as well.
Click to expand...
We have a security protocol in place. You'd think we were moving top secret material around, but people have done crazy stuff due to COVID.
 
GeneralVeers said:
That was my concern, based on my limited knowledge of how mRNA vaccines work. If the mRNA makes your cells pump out spike protein, would that trigger a greater, immune response if someone already has antibodies to COVID? Also, since the antibodies are already present, will that trigger an immune response against your own cells?
Click to expand...
The body will produce the spike protein for a little while, and then the mRNA will degrade (which is why you need a booster shot). I don't think it lasts for more than 24 hours actually.
 
Rekt said:
Agree. People still talking about masks too. Snooze fest.

With that said I'll be getting my vaccination next week. Surprised at how on top of stuff my hospital has been surprisingly.
Click to expand...
The sooner COVID numbers drop the sooner they can start filling those beds with elective surgery patients. Its purely a financial decision.
 
turkeyjerky said:
Are ya’ll getting much info from your hospitals on the actual logistics of vaccinations? Doesn’t seem like the tightest ship here...
Click to expand...
Yes, but my hospital has done a very good job with transparency for most of this pandemic already.
bravotwozero said:
they've already started setting up appointments for people at my hospital. I get my first shot in a week!
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I'm scheduled for a week from Monday, hopefully I'll find out which arm of the trial I'm in before then (I'm pretty sure I got placebo as I had ZERO symptoms with either injection)
southerndoc said:
My main fire department gig (where I'm medical director) is getting their first shipment on Monday. Odd how it was just approved but we're getting it first business day. The second set of doses will arrive 21 days later.
Click to expand...
I don't think it's that odd. I believe part of Operation Warp Speed was to have the potential vaccines getting manufactured ahead of time so as to cut down on delays. This was accomplished by governments committing ahead of time to buying doses in case they got approval. So the manufacturers looked at the data, saw that it would likely be approved, and started making and shipping doses. I'm not sure how much credit the POTUS deserves for Operation Warp Speed, but even haters like me should acknowledge that it has been an impressive success for this administration.
 
AMEHigh said:
So I can only speak for the trial I'm in...
They didn't test us beforehand or anything to know if we had active covid or antibodies.
They didn't even test us the day of our vaccine to see if we had active covid.
They did take a nasal swab on my first appointment and said they'd run it only if I developed covid like symptoms within the week of getting the vaccine to see if I actually had covid or if my symptoms were vaccine side effect.
So presumably some of the people who got the vaccine could've had antibodies already. I have not read if they've actually published any data about that. So far most of the trials have pretty promising safety data from the dozens of thousands of people in the trials, but of course there are still questions.
Click to expand...
The trial I am in drew blood before each vaccine dose, so I think they were testing for antibodies. I have no idea what the results were, however.
 
WilcoWorld said:
The trial I am in drew blood before each vaccine dose, so I think they were testing for antibodies. I have no idea what the results were, however.
Click to expand...

Same, mine also did NP swabs before each dose. And blood at the 1 month followup. the person drawing my blood told me that all of it (8 tubes!!) was to look for antibodies, but they haven't given us any results. I assume they would have told us if they found an active covid infection though.
 
GeneralVeers said:
Have they tested this mRNA vaccine on people who have recovered from COVID and developed an antibody response already?

A concern would be that programming your body to make large amounts of viral antigen, which your body is already primed to fight could trigger an intense immune response and lead to serious illness.
Click to expand...
prior COVID19 infection was an exclusion criteria for the NEJM Pfizer study of 40k patients.
 
Waiting for the next two weeks to figure when I can get mine. SO at a much bigger hospital system still hasn’t been told anything except “we expect to have the vaccine soon”. Not gonna lie, since this vaccine impacts a lot in our lives it’s kind of frustrating seeing my outpatient pediatrician friends getting it but not us.
 
Backpack234 said:
Waiting for the next two weeks to figure when I can get mine. SO at a much bigger hospital system still hasn’t been told anything except “we expect to have the vaccine soon”. Not gonna lie, since this vaccine impacts a lot in our lives it’s kind of frustrating seeing my outpatient pediatrician friends getting it but not us.
Click to expand...
Oof that’s terrible. Here in TN it seems it will go to the ER and covid units first. But first shipment is small so it’s all going to the big boys. But maybe some moderna for us little fish in a few weeks. We shall see.
 
Birdstrike said:
How'd they get it so soon?
Click to expand...
No idea. But plenty of Facebook posts in the last 24 hours showing scheduling emails and celebrating first doses. But they’re across the country from fl to cali to Louisiana.
 
Dr Mantis Toboggan said:
anybody on this board expecting to get vaccinated in the next few weeks?
Click to expand...
My outpatient group applied for vaccine but haven't heard anything yet. My other option is to get it from the hospital I'm on staff at. They were expecting shipment yesterday or today, then planning on sending out emails for people to self-schedule them. So, that looks promising. One other local hospital got them Mon or Tues and is already giving them, but I'm not on staff there.
 
Getting it in two days, on Thursday. They were going to schedule me for Weds, but my place is very strictly giving it 3 weeks apart, so I had to make sure I could schedule two shots separated by exactly 3 weeks. I can't wait to go get my hair cut after this (none of the hair places seem to mask around here). I am accidentally growing a mullet. It's a party in the back and emo kid/eyes covered in the front.
 
Cinclus said:
Getting it in two days, on Thursday. They were going to schedule me for Weds, but my place is very strictly giving it 3 weeks apart, so I had to make sure I could schedule two shots separated by exactly 3 weeks. I can't wait to go get my hair cut after this (none of the hair places seem to mask around here). I am accidentally growing a mullet.
Click to expand...

This is what i’m imagining of your last 9 months

www.9news.com

SC nurse excited to get COVID-19 vaccine: Besides patients, 'I have not touched another human being in nine months'

A local nurse in South Carolina said she can’t wait to get the vaccine because for nine months she’s lived in a car, a tent, and trailer to keep her family safe.
www.9news.com www.9news.com
 
wamcp said:
This is what i’m imagining of your last 9 months

www.9news.com

SC nurse excited to get COVID-19 vaccine: Besides patients, 'I have not touched another human being in nine months'

A local nurse in South Carolina said she can’t wait to get the vaccine because for nine months she’s lived in a car, a tent, and trailer to keep her family safe.
www.9news.com www.9news.com
Click to expand...

This person seems to be having a worse experience. I still see my spouse and pets all the time. But I trust them to likely not have COVID. Spouse has been very careful and does most work from home or completely away from others, wears N95 when in public, etc.
 
WilcoWorld said:
scheduled for Monday
Click to expand...
Weren't you in a vaccine study? I'm curious about it--did they unblind you, or are you just assuming you were in the placebo group? Its interesting, ethically I think study participants deserve to be in the first allocation of vaccinations, but its disappointing that we won't really have data on long-term efficacy.
wamcp said:
This is what i’m imagining of your last 9 months

www.9news.com

SC nurse excited to get COVID-19 vaccine: Besides patients, 'I have not touched another human being in nine months'

A local nurse in South Carolina said she can’t wait to get the vaccine because for nine months she’s lived in a car, a tent, and trailer to keep her family safe.
www.9news.com www.9news.com
Click to expand...
Eeesh. I don't understand how someone could live like that.
 
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