Off the market.
the FDA asked them to stop selling it...
from forbes.com:
A relatively small number of patients had heart problems, including chest pain, heart attacks and stroke, while on Zelnorm, but it appeared there was a large increase in risk when all 19,000 patients who got either Zelnorm or placebo were compared.
Of more than 11,000 patients treated with Zelnorm, 13 had serious and life-threatening cardiovascular side effects, according to the FDA. Four patients had a heart attack, and one died. Six had heart chest pain, or angina, that could lead to a heart attack. Three had strokes. Among the 7,000 people taking a placebo, only one had symptoms suggesting the beginning of a stroke; they went away without a problem.
the FDA asked them to stop selling it...
from forbes.com:
A relatively small number of patients had heart problems, including chest pain, heart attacks and stroke, while on Zelnorm, but it appeared there was a large increase in risk when all 19,000 patients who got either Zelnorm or placebo were compared.
Of more than 11,000 patients treated with Zelnorm, 13 had serious and life-threatening cardiovascular side effects, according to the FDA. Four patients had a heart attack, and one died. Six had heart chest pain, or angina, that could lead to a heart attack. Three had strokes. Among the 7,000 people taking a placebo, only one had symptoms suggesting the beginning of a stroke; they went away without a problem.
Does anyone know the mechanism by which Zelnorm might possibly cause this increased risk? I can't find that info anywhere