Is it impossible to apply? No, nothing is impossible. Perhaps the better question is how will those 2C- and 2D affect your application. Normally, if you have a high GPA, like 3.6+, then 1 C- or 1 D won't affect your application. However, you have not just 1 but 2C-, and on top of that 2D, and your GPA is at the minimum side... Its all of these combined factors that reduce your chance to get an interview invitation/acceptance letter. Another important factor is what school you are applying and where. Perhaps less competitive schools in some low population states will consider your application The schools in CA are very competitive due to the large applicant pool so I highly doubt you will get any chance of getting an interview if you apply.
Due to the intense competition nature of the program, I think you will have to prove yourself "extraordinary" in your other areas such as volunteer/community/leadership/work/essays in order to balance out your low grades. Even if you retake the classes, the grades are always there, they don't just disappear.
Don't get me wrong. I'm not saying its impossible for you to get into a pharmacy school, but I think it is very difficult for you to even get an interview invitation. Like I said, your essays/volunteer/leadership/community services need to be better than the other applicants who have higher GPA/better grades than you do.