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alkylating vs intercalation vs cross linkage

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westernmed007

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-Intercalation (dactinomycin, doxyrubicin, bleomycin
) is when somehow you shoot stuff (I assume the free radicals in doxy/bleo, what about dactinomycin?) in between two strands of DNA and get them all tangled up and they can't be expressed.


-Alkylating (cisplatin, carmustine, cyclophosphamide, busulfan) some how adds groups (something like a methyl group) to the DNA to make it stick together? (I.E. "cross linking?") This in turn decreases transcription/translation?

So I guess alkylating is like rubbing a strand of fishing line on the ground until some of it breaks and some of it like gets super tangled, while alkylation would be like throwing a gob of glue over a spool of fishing line so it can never be unwound.
 
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