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what a f'n joke..
why is this drug out there? i really would like a serious answer to this, because i don't know if i'm missing something or not.
I guess the only notable difference is that one undergoes an anti-markovnikov reaction and the other doesn't.
*runs before getting shot*
Actually, fluticasone propionate and fluticasone fumarate are not salts, but rather describe ester side chains on a fluticasone backbone. Neither is metabolized to fluticasone in humans.Look at Veramyst and generically available Flonase, the only difference is the salt. These are just patent extenders. There is no good reason for this drug except money.
Studies have shown that people who are told their drug is more expensive find it to be more effective. Don't blame your misunderstanding of psychology on my understanding of pharmacology & biochemistry.I have to say, I see a fair bit of arrogance in this thread. People can react very differently to the same medication. Just because you think you understand chemistry, you thing you can judge a person's reaction to a drug. In practice, for some, this drug is less effective and has more side effects than others. For others, it is a literal lifesaver. Given that so many varied responses can happen from even the same medication, it is important to have more tools in the tool shed. I personally know someone for whom this medication was an enormous improvement over others that "should have been" nearly chemically equivalent. We are complicated creatures, us humans.
Studies have shown that people who are told their drug is more expensive find it to be more effective. Don't blame your misunderstanding of psychology on my understanding of pharmacology & biochemistry.
Yes, we are complicated, which means that evaluating the relative clinical effectiveness of various anti-depressants is difficult. Are you familiar with all the subjective measures and the weaknesses of HAM-D scores and the difference between statistical significance and clinical significance? Do you know about "evergreening," such as the introduction of escitalopram to supplant citalopram, and all the Lundbeck-funded studies resulting in a finding of statistically significant superiority of escitalopram, to the (surprise!) benefit of Lundbeck's newly-patented escitalopram and the detriment of (newly genericized) citalopram?I have to say, I see a fair bit of arrogance in this thread. People can react very differently to the same medication. Just because you think you understand chemistry, you thing you can judge a person's reaction to a drug. In practice, for some, this drug is less effective and has more side effects than others. For others, it is a literal lifesaver. Given that so many varied responses can happen from even the same medication, it is important to have more tools in the tool shed. I personally know someone for whom this medication was an enormous improvement over others that "should have been" nearly chemically equivalent. We are complicated creatures, us humans.
I came across this site because before today, I had never heard of Aplenzin. I agree that patients can and do have varied reactions to different medications, even the same drug that is made by different generic drug companies. However, it's difficult to believe that Aplenzin is much more tolerable than Wellbutrin, Wellbutrin SR or Wellbutrin XL based on the reaction of the hydrobromide salt. Generic Wellbutrin XL has an AWP of about $4.85 per tablet. The equivalent dose of Aplenzin has an AWP of about $57.85 per tablet (oddly enough, brand name Wellbutrin XL cost about the same as Aplenzin, both manufactured by Valeant Pharmaceuticals). That's a HUGE price difference between the generic Wellbutrin XL and Aplenzin. I'm skeptical that the difference in salts justifies such a drastic price increase. Considering brand name Wellbutrin XL (with an available generic) cost about the same as Aplenzin (brand name only), this seems like pure greed on Valeant's behalf (and GSK with the Wellbutrin to the Wellbutrin SR to the Wellbutrin XL, not to mention Zyban).I have to say, I see a fair bit of arrogance in this thread. People can react very differently to the same medication. Just because you think you understand chemistry, you thing you can judge a person's reaction to a drug. In practice, for some, this drug is less effective and has more side effects than others. For others, it is a literal lifesaver. Given that so many varied responses can happen from even the same medication, it is important to have more tools in the tool shed. I personally know someone for whom this medication was an enormous improvement over others that "should have been" nearly chemically equivalent. We are complicated creatures, us humans.
I have to say, I see a fair bit of arrogance in this thread. People can react very differently to the same medication. Just because you think you understand chemistry, you thing you can judge a person's reaction to a drug. In practice, for some, this drug is less effective and has more side effects than others. For others, it is a literal lifesaver. Given that so many varied responses can happen from even the same medication, it is important to have more tools in the tool shed. I personally know someone for whom this medication was an enormous improvement over others that "should have been" nearly chemically equivalent. We are complicated creatures, us humans.
I have to say, I see a fair bit of arrogance in this thread. People can react very differently to the same medication. Just because you think you understand chemistry, you thing you can judge a person's reaction to a drug. In practice, for some, this drug is less effective and has more side effects than others. For others, it is a literal lifesaver. Given that so many varied responses can happen from even the same medication, it is important to have more tools in the tool shed. I personally know someone for whom this medication was an enormous improvement over others that "should have been" nearly chemically equivalent. We are complicated creatures, us humans.
Created an account just to prove that most of the people on this thread are, in fact, arrogant. Maybe if you guys attempt to engage in even the most basic level of research (e.g. a simple Google search) next time you can avoid this mistake in the future.
https://www.ncbi.nlm.nih.gov/pubmed/19557114/
lolCreated an account just to prove that most of the people on this thread are, in fact, arrogant. Maybe if you guys attempt to engage in even the most basic level of research (e.g. a simple Google search) next time you can avoid this mistake in the future.
https://www.ncbi.nlm.nih.gov/pubmed/19557114/
Created an account just to prove that most of the people on this thread are, in fact, arrogant. Maybe if you guys attempt to engage in even the most basic level of research (e.g. a simple Google search) next time you can avoid this mistake in the future.
https://www.ncbi.nlm.nih.gov/pubmed/19557114/
bupropion HCl 125 mg/kg induced a significantly higher ten-fold increase in the mean number of cortical EEG seizures compared to bupropion HBr
Ummmm.....
So, if a 200lb patient is taking eleven thousand milligrams of Wellbutrin, it would be safer for them to be on Aplenzin. I'll keep that in mind.
No, not regardless of dosage. Dosage is very important. Your single study on rodents using doses nearly 100 times the normal human dose proves very little.Regardless of the dosage this is still a significant response that you completely disregard; this thread is an echo chamber. If you are medical doctors you should be ashamed... thank you for further proving my point.
No, not regardless of dosage. Dosage is very important. Your single study on rodents using doses nearly 100 times the normal human dose proves very little.
Also, you're resurrecting a thread from 2011.
LOL.Read the link I posted from the FDA. Actual dosage response doesn't necessarily translate to expected response at a different dosage, and this study should not be disregarded precisely for that reason. The high dosage in the study was NECESSARY to induce seizures in the mice population because it should be assumed that most mice are not prone to seizures, much like humans. It would be unethical to test this on seizure-prone humans, although the hydrobromide salt would possibly display a significant reduction in seizures when compared to a hydrochloride salt. If a seizure-prone patient benefits from Wellbutrin, the results of such a study would be crucial in determining a prescription that exerts the most benefits with the least side-effects, such as seizures. If you could get past your arrogance you would consider ALL data available in prescribing drugs.
Have you ever eaten an almond flavored cookie?Read the link I posted from the FDA. Actual dosage response doesn't necessarily translate to expected response at a different dosage, and this study should not be disregarded precisely for that reason. The high dosage in the study was NECESSARY to induce seizures in the mice population because it should be assumed that most mice are not prone to seizures, much like humans. It would be unethical to test this on seizure-prone humans, although the hydrobromide salt would possibly display a significant reduction in seizures when compared to a hydrochloride salt. If a seizure-prone patient benefits from Wellbutrin, the results of such a study would be crucial in determining a prescription that exerts the most benefits with the least side-effects, such as seizures. If you could get past your arrogance you would consider ALL data available in prescribing drugs.
Also, a seizure prone patient on any form of bupropion should sue their doctor for malpractice.Read the link I posted from the FDA. Actual dosage response doesn't necessarily translate to expected response at a different dosage, and this study should not be disregarded precisely for that reason. The high dosage in the study was NECESSARY to induce seizures in the mice population because it should be assumed that most mice are not prone to seizures, much like humans. It would be unethical to test this on seizure-prone humans, although the hydrobromide salt would possibly display a significant reduction in seizures when compared to a hydrochloride salt. If a seizure-prone patient benefits from Wellbutrin, the results of such a study would be crucial in determining a prescription that exerts the most benefits with the least side-effects, such as seizures. If you could get past your arrogance you would consider ALL data available in prescribing drugs.
http://www.fda.gov/AboutFDA/CentersOffices/OfficeofMedicalProductsandTobacco/CDER/ucm153270.htm
Remember this? Probably not, or you simply disregard this, too. Not all drugs are created equal, but I'm sure if a patient came to you complaining about their Teva generic of Wellbutrin XL you would tell them generics are identical and that their symptoms were psychosomatic.