Ursus Martimus said:
No one in their right mind will equate the relative risks smoking with shift work as far as CAD risks. You quote the Scand J Work Environ Health vs the NEJM - nice. I'm sure you can dig up the literature to prove almost anything, but if you honestly think that smoking and shift work are equivalent risks, who knows what else you will believe. God help me if I end up in the ED where you work.
Wow, you sure love to jump to conclusions. Now, let's address your "critiques" in order.
First you state "No one in their right mind will equate the relative risks smoking with shift work as far as CAD risks" then fail to offer any scientific proof to back up this statement. Isn't that what you accused 12R34Y of?
Second you claim that "{I} quote the Scand J Work Environ Health vs the NEJM - nice." Actually, I do no such thing. To quote the
study you posted:
"We prospectively examined the incidence of coronary heart disease in relation to cigarette smoking in a cohort of 119,404 female nurses who were 30 to 55 years of age in 1976 and were free of diagnosed coronary disease. During six years of follow-up, 65 of the women died of fatal coronary heart disease and 242 had a nonfatal myocardial infarction. The number of cigarettes smoked per day was positively associated with the risk of fatal coronary heart disease (relative risk = 5.5 for greater than or equal to 25 cigarettes per day), nonfatal myocardial infarction (relative risk = 5.8), and angina pectoris (relative risk = 2.6). Even smoking 1 to 4 or 5 to 14 cigarettes per day was associated with a twofold to three-fold increase in the risk of fatal coronary heart disease or nonfatal infarction." {emphasis added}
So they looked at
nurses without controlling for shift work. Oops - doesn't really help your argument. So then I posted a
study that stated:
"The relative risks were 1, 1.6[95% confidence interval (95% CI) 1.1-2.5], 1.3(95% CI 0.9-2.1), and 2.7(95% CI 1.8-4.1) for the following combinations of shift work (SW) and smoking (SM): SW-&SM-, SW-&SM+, SW+&SM-, and SW+&SM+, respectively; and the corresponding figures for shift work and obesity (BMI > or =28 kg/m2) were 1, 1.2(95% CI0.8-1.9), 1.3(95% CI0.9-1.9), and 2.3(95% CI1.5-3.6), respectively. In both cases the effect was at least multiplicative. For the shift workers the relative risk for CHD rose gradually with increasing numbers of adverse life-style factors, but for the day workers there was no clear dose-response pattern. CONCLUSIONS: Shift work seems to trigger the effect of other, lifestyle-related risk factors of CHD and therefore calls for active prevention among shift workers."
So to translate (since you don't seem to actually read what you post): smoking bad, shift work bad, smoking plus shift work even worse. The Scandinavian journal's findings have been duplicated by many other sources (as I posted). If you can find a NEJM article that directly compares the two risks (smoking and shift work) and that repudiates the study above, please post it. Otherwise it seems that the studies actually
agree (as one could safely assume at least some of the 100K nurses in the NEJM article did perform shift work).
BTW - While the NEJM is certainly one of the most well respected journals in medicine, the Scandinavian Journal of Work, Environment & Health is actually quite well respected within occupational medicine. It's ISI aggregate impact factor is 1.99 as compared to the industry average of 1.56. So I wouldn't be too quick to dismiss the findings.
You then (again) resort to ad hominum attack, "I'm sure you can dig up the literature to prove almost anything, but if you honestly think that smoking and shift work are equivalent risks, who knows what else you will believe". I'll save you time. I believe that a careful literature review can demonstrate various risks for health alterations. I also believe that when attempting to compare risks, "head-to-head" studies that directly compare those risks are more meaningful than attempting to meta-analyze other papers where obvious confounders might come into play (regardless of where they are published).
Apparently you read program materials as closely as you do journals, leading you to "threaten
lawsuits" against ERAS over $25?!? I hope that you learn to read more critically prior to actually practicing RadOnc. Good luck with the match.
Lastly, "God help me if I end up in the ED where you work." I'm sure sorry you feel that way. I'll endeavor, none the less, to treat you in the manner best supported by evidence should such an untoward event come to pass.
- H