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Discussion in 'Medical Students - MD' started by BlondeCookie, Dec 5, 2005.
Is acetyl CoA the same thing as acyl Coa?
acetyl = 2 carbon
acyl = n number of carbon
I think acetyl Coa is refering specifically to the 2 carbon CoA citric acid cycle intermediate, while acyl Coa refers to any longer carbon chained CoA (such as a fatty acid that has been thioesterefied in preparation for beta oxidation).
Thanks guys. SO, acyl and acetyl just refer to the number of carbons attached to the CoA. What about acetoacetyl Coa? Is this an acyl Coa? How many carbons?
I think (and if I'm wrong a neurotic predmed/gunner please correct me) that acetoacetyl CoA is 2 acetyl CoA molecules condensed, and is the one of the major reactants in cholesterol synthesis
To follow up on what andiluvsk said:
Acetoacetyl CoA is the condensation product of two acetyl CoA molecules and an intermediate along the pathway to the ketone bodies. The condensation of acetoacetyl CoA with a third acetyl CoA molecule yields HMG CoA. HMG CoA is reduced to mevalonic acid in the synthesis of cholesterol. It is this reduction step that is regulated in cholesterol production.