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Biochem Q, nomenclature

Discussion in 'Medical Students - MD' started by BlondeCookie, Dec 5, 2005.

  1. BlondeCookie

    BlondeCookie Senior Member
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    Is acetyl CoA the same thing as acyl Coa?
     
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  3. slick177

    slick177 Junior Member
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    acetyl = 2 carbon
    acyl = n number of carbon
     
  4. andiluvsk

    andiluvsk Member
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    I think acetyl Coa is refering specifically to the 2 carbon CoA citric acid cycle intermediate, while acyl Coa refers to any longer carbon chained CoA (such as a fatty acid that has been thioesterefied in preparation for beta oxidation).
     
  5. BlondeCookie

    BlondeCookie Senior Member
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    Thanks guys. SO, acyl and acetyl just refer to the number of carbons attached to the CoA. What about acetoacetyl Coa? Is this an acyl Coa? How many carbons?
     
  6. andiluvsk

    andiluvsk Member
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    I think (and if I'm wrong a neurotic predmed/gunner please correct me) that acetoacetyl CoA is 2 acetyl CoA molecules condensed, and is the one of the major reactants in cholesterol synthesis
     
  7. sandg

    sandg Senior Member
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    To follow up on what andiluvsk said:
    Acetoacetyl CoA is the condensation product of two acetyl CoA molecules and an intermediate along the pathway to the ketone bodies. The condensation of acetoacetyl CoA with a third acetyl CoA molecule yields HMG CoA. HMG CoA is reduced to mevalonic acid in the synthesis of cholesterol. It is this reduction step that is regulated in cholesterol production.
     

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