I wonder if you are referring to the shift between the Aldehyde and Cyclic forms of glucose.
I know the cyclic form is favored under physiologic-pH (~7-7.2). But I think in more acidic conditions the equilibrium may shift towards the non-cyclic aldehyde conformation.
But back to more of your question, it takes the addition of ATP(s) and many enzymes for the METABOLIC breakdown of glucose. Think of glycolysis, specifically the ATP's added by the kinases to build the 6-C molecule to an energy state favorable for the split into 2x 3-C molecules by the enzyme Aldolase. (into glyceraldehyde 3-P or dihydroxyacetone Phosphate)