Step I C diff toxins

[acciddropping]

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Out of two toxins C. diff produce, which one is responsible for pseudomembrane colitis? In FA, it sounds like toxin B being cytotoxic and causes the colitis- but it was not clear whether A is also needed or contributes to the onset.

Thanks.

 

[Enzymes]

My bad, I think A allows the entry of B (I think this is how all AB toxins work)

 

[NeuroLAX]

Toxin A gives you the watery squirts. Toxin B is the cytotoxic one that gives you the pseudomembrane

 

[Enzymes]

So A is not involved in the entry of B?

 

[NeuroLAX]

So A is not involved in the entry of B?

Haven't heard of that... sounds more like anthrax. Although, somehow the toxin B is causing intracellular affects on actin, so... not sure what's up with that.

 

[Enzymes]

Its weird bc I know that C difficile has an AB toxin. However, the normal AB toxin acts so that B binds, and A is released into the cytoplasm and exerts effects (like ADP robsylation).

Sounds almost like A and B toxins are just completely separate here....confusing.

 

[acciddropping]

So A is not involved in the entry of B?

I think that C diff's A and B is different from the other A/B toxins where A is active and B is binding.

 

[acciddropping]

Toxin A gives you the watery squirts. Toxin B is the cytotoxic one that gives you the pseudomembrane

Sounds good! Txks