If one has an outstanding GPA and competitive MCAT score with good ECs, can weak/average LORs, destroy your chances of being accepted? I know I have 1 really good rec letter, but the remaining 4, I feel are unattached/possibly weak. I basically did well in those classes and asked the professor for a letter at the end, which i only went to office hours maybe once or twice with them. They probably wrote something general like "Got good grades, came to every class" but I doubt they wrote anything about my character, etc. The 1 really good letter is from my PI, and thats due to research commitments. Will these weak LORs ruin my chances if the rest of my app is good? Or is LOR a system, where only negative comments will red flag you and everything else will not really have an impact? My relevant classes are all 200+ students so it's really hard for people to build a relationship with professors. They usually refer you to the TAs of the class for any questions due to the large class size. And many other classes have office hours by appointment and no set schedule for office hours, so it's kinda awkward to email them every week asking for them to come in to talk to me when I'm not having trouble in the class. In summary, will average/weak LORs ruin my chances? How can I get good LORs from a professor when I'm not struggling in the class and office hours with the professor is not easily possible?