My husband filled in the disadvantaged part of his AMCAS and I think it was to his benefit, but be careful to keep it positive. If you have a disadvantaged background, you can use that forum to complain about how much harder it has been on you, but that would be inadvisable. I came from an advantaged background myself, and personally I am inspired to hear about people making it in spite of bad circumstances. I had everything going for me, and I still managed to attempt to mess up my life beyond repair... My husband, who I met after my life was back on track, came from a migrant farmworking family, his parents have no education, he lived in a trailer with 14 other people, he didn't even have to go to school because nobody cared at all. But, in his disadvantaged statement he focused on what he learned from his background: hardworking family, learning to work independently, etc. He mentioned the hardships he faced, but didn't do it in a whiny way. Rather, it was *inspiring* if I may be so bold... He's been to 7 interviews, and almost all of his interviewers have been impressed by his story, much of which they learned through the disadvantaged statement. By all means, be personal in it because this is what will set you apart, and your ultimate goal is to get in. BTW, he got in. Hope this helps.