So, here's a question I have as a naive undergrad. Does someone choose a project thinking, "This project is high caliber. If I get it done, it's going in Nature" or do Nature papers just happen from regular work that gets lucky? I ask this because it seems there are big shot labs out there that regularly publish in Nature while there are big shot labs that don't. I work in a big shot lab, my PI is editor of a very major journal, chair of dept, etc. but almost no papers end up in high impact factor journals. All the work is just ho-hum observational stuff that gets churned out to mid-level journals. So, are Nature-worthy projects chosen and specifically sought after or do they just happen?