Epinephrine Reversal Effect

[hrtsurgeon2b]

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Does anyone know how you can epinephrine reversal effect?

 

[Idiopathic]

I believe phentolamine is the way to go, if you are looking for a way to try to reverse epi-induced affect.

 

[InductionAgent]

Phentolamine or another selective alpha-blocker will give you a classic "epinephrine reversal" effect in terms of producing vasodilation and hypotension in a lab experiment.

In a clinical situation of reversing an excessive dose of epinephrine, pure alpha blockade would be imprudent. If the patient is already tachycardic from the epinephrine, dropping the blood pressure would exacerbate it. (Pure beta-blockade would be equally imprudent, for the opposite reason that it would result in unopposed alpha-stimulation that would produce profound vasoconstriction.)

The OP needs to clarify exactly what he or she is asking.

 

[Idiopathic]

Well in that case you would just Rx as you would an acute pheo, with phentolamine/propranolol (or somesuch), correct?

 

[InductionAgent]

Well in that case you would just Rx as you would an acute pheo, with phentolamine/propranolol (or somesuch), correct?

I would think so.