Do you feel there is a significant difference in quality? I've had people try to argue both sides.
Do you feel there is a significant difference in quality? I've had people try to argue both sides.
No, generics have to prove to the FDA that they're just as good as the "real thing." I think a lot of patients don't realize this, that the generics are still regulated.Do you feel there is a significant difference in quality? I've had people try to argue both sides.
As far as i know, the active ingredients of both brand and generic will be same but the inactive ingredients may be different. For narrow therapeutic index drug like warfarin, levothyroxin etc, you want to stick with one type.. thats what i have understood.
Ray
I do agree that with the narrow TI drugs, switching might be more of a concern, but I don't think it's a reason not to switch. The patient and his/her doctor just need to be aware that there might be some fluctuations in serum drug concentrations during the switch...so the doctor just needs to monitor the patient more frequently during this time and be aware that the dose may need to be adjusted (i.e. 112 mcg Levoxyl may correlate to 125 mcgh of levothyroxine for that patient). If the patient will be compliant with coming in for blood tests (checking the INR with warfarin, checking TSH with levothyroxine), then go for it. One of our professors also said that switching to generic phenytoin was also problematic at times.Someone I know has been taking Levoxyl for at least the past 5 years. She has no problem with generics but the doctor prescribed Levoxyl and for some reason, CVS didn't have levothyroxin as a generic sub for Levoxyl (it was only a sub for Synthroid). Now, CVS has changed it so that it does come up as a generic sub. From what you said, it seems as if she should stick with Levoxyl. It's not a monetary issue since the copay is the same, but wouldn't it be better for everyone (except Levoxyl's company) to go with the generic? It would save the insurance company money and in turn the members (particularly if its a non profit organization).
Should I tell her to change to the generic or stick with Levoxyl since she's been taking it for a long time now? The main reason for the question is that I don't know if there was a reason it didn't come up as a sub before or if the difference of inactive ingredients would make a difference here since its a low therapeutic index drug (assuming she's not allergic to either). I'm in Rutgers Pharmacy School right now. But I'm only in the first professional year so I can't answer this question (looks like it could be a therapeutics issue). I would really appreciate any comments on this.
I didn't think any products were AB rated for Synthroid...Does NJ not use the Orange Book? Or have I just confused it with one of the other thyroid preps?! Anyone have any insight?CVS didn't have levothyroxin as a generic sub for Levoxyl (it was only a sub for Synthroid).
I didn't think any products were AB rated for Synthroid...Does NJ not use the Orange Book? Or have I just confused it with one of the other thyroid preps?! Anyone have any insight?
I've always said they were the same thing.
but I recently changed OC to a different generic (Microgestin to Junelle)
HUGE difference. moodier, crampier, n+v, etc etc etc.
makes me not want to change other meds that just went generic and pay the $$ for brand. I've decided patients aren't always full of crap and it's not just a placebo effect as I didn't expect any change at all and it took me a couple weeks to realize that if I miss one and take 2 of these at night I will feel like crap in the morning and quite possibly throw up. Never was an issue in the past.
As far as i know, the active ingredients of both brand and generic will be same but the inactive ingredients may be different. For narrow therapeutic index drug like warfarin, levothyroxin etc, you want to stick with one type.. thats what i have understood.
Ray