Quantcast

Glaucoma and Pregnancy

This forum made possible through the generous support of SDN members, donors, and sponsors. Thank you.

Luxman

Full Member
10+ Year Member
Joined
Aug 18, 2008
Messages
13
Reaction score
0

Members don't see this ad.
Hi!
I have made some research on Pubmed regarding this topic but I couldn't find an answer to the following question: which IOP lowering eyedrop can be, rather safely, be used during pregnancy? Thank you for sharing your knowledge ;)
 

Wolverine98

Full Member
10+ Year Member
5+ Year Member
Joined
Oct 13, 2006
Messages
264
Reaction score
2
There's often a lowering or IOP during pregnancy anyway, so in early glaucoma you can often stop meds and watch them closely. I've had a couple of patients simply tell me that they're not going to take anything until after they're done breast-feeding, so then this is the only option anyway. With a little worse disease, I like to go for laser trabeculoplasty as my first option of treatment.

Big caveat here. I don't have my books with me right now, so if someone has access to a text in front of them, and they disagree with what's here, go with that.

Beta blockers are used systemically for HTN and congenital heart issues (in the mother), and are felt to be generally safe, but with some definite potential issues (respiratory depression, prolonged labor, hypotension, IUGR, fetal bradycardia, to name a few). Timolol does cross the placenta and into breast milk. It's class C in the first trimester and D in the 2nd and 3rd.

Prostaglandins are used to induce labor, and, theoretically, topical prostaglandin analogs could induce early labor. For this reason, I don't like to use them in this situation. They're class C.

Alphagan is a tough one. It's class B, which is good. However, it's also well known for causing respiratory and CNS depression in infants, and it is secreted in breast milk, so if you decided you could use it in pregnancy, you'd want to stop it after delivery.

The CAIs (topical and oral) are class C; there are some limb deformities at high doses with acetazolamide. Acetazolamide is secreted in breast milk, but I don't remember about the topical CAIs.

If I have a patient who has fairly advanced glaucoma, and wishes to get pregnant, but has not yet, then we talk about doing filtering surgery prior to pregnancy, and that's a long, involved discussion.
 

Luxman

Full Member
10+ Year Member
Joined
Aug 18, 2008
Messages
13
Reaction score
0
Thanks! This is pretty useful ;-)
 

V05

Full Member
10+ Year Member
Joined
Apr 3, 2007
Messages
47
Reaction score
1
I agree with the above- I would consider beta-blocker and trabeculoplasty first followed by filtering surgery (however, I would not use antimetabolites during pregnancy).
 

Wolverine98

Full Member
10+ Year Member
5+ Year Member
Joined
Oct 13, 2006
Messages
264
Reaction score
2
(however, I would not use antimetabolites during pregnancy).

Absolutely; thanks for pointing it out.
In fact, when we had a pregnant fellow, she had to take a break from the cases where we used Mito.
 
Top