A few years ago, I applied to Texas schools.
I'm out of state - from Pennsylvania. Lived my entire life in Pennsylvania, actually. I have NO family members who live in Texas. I've never even BEEN to Texas.
I was offered an interview at UT San Antonio - didn't get anything else from the other Texas schools.
The only reason, I'm sure, that I was offered an interview at UTHSCSA, is because I speak Spanish pretty well - and it showed on my application. (I did an internship in Spain, was a language tutor, took graduate level classes conducted in Spanish, etc.) And I was really interested in helping Hispanic underserved patients (still am, in fact).
If you don't speak Spanish, or show some kind of dedication to a large patient population group in Texas, AND you have no ties to the area, don't bother. The TMDSAS application is VERY tedious to fill out (I thought it was even worse than AMCAS), and quite expensive.