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Hyponatremia in nephrotic syndrome

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Kinis

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Was looking at a clinical tutorial we has with a nephrotic syndrome case, and saw that the pt had low plasma na+, when discussing it, what I gathered was that it was due to a relatively large amount of na+ (explaining the hypokalemia) being diluted in an even larger amount of retained water (leaked into the 3rd space). Is that the case?
 

AndyRSC

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That is correct. Most cases of hyponatremia are due to elevation of water relative to sodium.

In nephrosis, you're losing your protein, which causes you to lose intravascular osmotic pressure, which causes water to leave the vessels and accumulate in tissues (edema), which causes a reduction in effective arterial volume, which causes water and sodium retention (but more water than sodium due to ADH).
 

Kinis

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That is correct. Most cases of hyponatremia are due to elevation of water relative to sodium.

In nephrosis, you're losing your protein, which causes you to lose intravascular osmotic pressure, which causes water to leave the vessels and accumulate in tissues (edema), which causes a reduction in effective arterial volume, which causes water and sodium retention (but more water than sodium due to ADH).
Thanks :thumbup:
 
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