During fasting, hypoglycemia will trigger GH, and I thought GH would trigger Inuslin like growth factor in the liver, but it does not? Does anyone know why?
IGF decreased during fasting, why?
- Thread starter Onigiri
- Start date
I can't remember which author, but in my class, it was presented as such. In the fed state with protein, growth hormone is increased as well as IGF. In the fed state with carbohydrates, GH decreases, and IGF stays the same. During fasting, GH goes up, but IGF decreases.
- Joined
- May 24, 2017
- Messages
- 248
- Reaction score
- 85
GH is produced during times of stress. Just like cortisol, GH promotes insulin-resisitance. For this reason, during the fasting state/hypoglycemia, GH is increased (which acts on the liver to produce IGF-1). This is so that during states of low glucose, GH is produced so that glucose can be taken up by the brain (via GLUT-1 receptors which is insulin independent, so GH does not decrease glucose uptake in the brain) instead of adipose and striated muscle (GLUT-4 which is insulin dependent).
The mechanism/regulation is as follows: during fasting state, the GI tract produces ghrelin which, in part, acts on the hypothalamus to stimulate growth hormone release.
Hope this helps!
The mechanism/regulation is as follows: during fasting state, the GI tract produces ghrelin which, in part, acts on the hypothalamus to stimulate growth hormone release.
Hope this helps!
