Increased triglycerides - nephrotic syndrome

[Phloston]

Advertisement - Members don't see this ad

Why are triglycerides increased in nephrotic syndrome? Is it merely increased hepatic production or is there another mechanism?

Basic question, I know, but I'd appreciate someone's helpful input.

 

[Boardz]

Why are triglycerides increased in nephrotic syndrome? Is it merely increased hepatic production or is there another mechanism?

Basic question, I know, but I'd appreciate someone's helpful input.

pathoma dude said it's like the liver is compensating for protein loss in the urine by increasing production of triglycerides.

 

[alternatego]

pathoma dude said it's like the liver is compensating for protein loss in the urine by increasing production of triglycerides.

yeah, but he said the liver is "sort of" compensating IIRC, as far as I remember the exact mechanism of why this happens has not been established yet

 

[Aclamity]

yeah, but he said the liver is "sort of" compensating IIRC, as far as I remember the exact mechanism of why this happens has not been established yet

This. No one knows for sure. but some posit that when you upregulate the protein synthesis pathways in the liver you nonspecifically upregulate fat synthesis pathways.

 

[Belleza156]

Goljan says that the hypoalbuminemia created by the protein loss increases synthesis of cholesterol by an unknown mechanism.