I only read through RR Path all at once during dedicated Step 1 study, but I felt it was immensely helpful for long-term retention to read a chapter, close the book, and reproduce all the information and concepts from the chapter in a notebook. I only did this once for each chapter, but this really helped me integrate and understand everything, to the point where I still feel like I know pathology pretty well even though I haven't done anything clinical in months...
I actually thought it was pretty important to do well in class on top of studying for the boards; I explicitly remember getting questions correct on Step 1 because of information I had learned only from class and not any review resource. Internal data from my own medical school shows that preclinical course exam scores have by far the strongest positive correlation with our students' Step 1 scores (even though our grading is "true P/F").