The question is just way too broad.
Lets start with how you define small animal. are you limiting it to dog/cat, or do you include exotics and pocket pets? then, are you limiting it to general practice, or speciality and emergency? within those, owner or associate? holistic?
on to large animal. are you including horses? or are you seperating those into equine vs food animal? are you including all food animal in the US or just the 'traditional' ones? are you asking about industry ag, of small farm? dairy production or meat? large expanse or stock yard? Temple or Bud?
that is why I said it depends. I personally think an emergency practice owner that also provides services for exotics is a more challenging job than a large animal food industry vet, but I would be willing to argue that a cat only practice associate vet isn't as challenging as a family farm dairy practicioner, or a livestock handling expert.
The biggest difference, in my personal opinion, will be the utilization of animals. Are they resources or not? if so, how? emotional, food, product, etc? I believe the essential skills of palpation, diagnostics, etc aren't going to be inexplicably different (otherwise vet schools would already specialize which is a different debate.) I also think in non equine LA there is a lot more concern with return on investment, that you won't see in pets unless you are dealing with working animals. IE most dog owners aren't going to worry about whether their dog earns it's keep, but of course, there are exceptions; stock dogs, sniffing dogs, SAR dogs need to earn their keep, but the end result of failure to do so isn't likely ending up in a processing plant.