S steppingstone Full Member 10+ Year Member Jan 27, 2013 #1 Advertisement - Members don't see this ad can someone please explain what LDA does/ what common reactions is it found in? also, for E2, when there isn't a bulky base...does it follow mark addition?
Advertisement - Members don't see this ad can someone please explain what LDA does/ what common reactions is it found in? also, for E2, when there isn't a bulky base...does it follow mark addition?
I IsaacYankem Full Member 10+ Year Member Jan 27, 2013 #2 LDA is a strong base used to remove alpha-hydrogens in many ketone/aldehyde alpha addition reactions. E2 reactions go markovnikov if no bulky base is present and the more substituted side has an anti-periplaner H to leave. Upvote 0 Downvote
LDA is a strong base used to remove alpha-hydrogens in many ketone/aldehyde alpha addition reactions. E2 reactions go markovnikov if no bulky base is present and the more substituted side has an anti-periplaner H to leave.
