Lysosomes

[OU11BB]

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if any of the enzyme escapes the vesicle, would it be neutralized by the cytosol, or would it kill the cell?

 

[dentrilla]

if any of the enzyme escapes the vesicle, would it be neutralized by the cytosol, or would it kill the cell?

The pH in the lysosome (4.5ish) is much more acidic then then the cytosol(7.2ish). All the digestive enzymes in the lysosome are made to run at the acidic pH and I would assume that they do not function @ 7.2pH. Active sites get deprotonated/protonated when pH changes and dramatic changes can even cause the proteins to denature.

Hope that helps!

 

[OU11BB]

yes it does thanks alot!

 

[marscole]

Yes... Normally, if the materials in the lysosomes come out and leak into the cytosol, the cells are undergoing apoptosis.

Also, link that to the disease called Tay-Sach. (Know a general background of this disease!!) 😉

 

[dentrilla]

Yes... Normally, if the materials in the lysosomes come out and leak into the cytosol, the cells are undergoing apoptosis.

Also, link that to the disease called Tay-Sach. (Know a general background of this disease!!) 😉

I always thought the enzymes in the lysosomes acidic environment don't run at the basic pH of the cytosol?

I know for sure that they are at their optimum pH in the lysosome.

 

[ZzZzSleepyhead]

Strange, I thought the same thing as dentrilla. I think that's what it says in Cliffs AP Bio 😵?😱

 

[dentrilla]

I just wiki'd(yay for wiki) Tay-Sach and it proves my answer correct 😉

" TSD is caused by insufficient activity of an enzyme called hexosaminidase A that catalyzes the biodegradation of fatty acid derivatives known as gangliosides. Hexosaminidase A is a vital hydrolytic enzyme, found in the lysosomes, that breaks down lipids. When Hexosaminidase A is no longer functioning properly, the lipids accumulate in the brain and interfere with normal biological processes."

Hexosaminidase A no longer functions because it's not in the lysosomes!

 

[navneetdh]

Yes... Normally, if the materials in the lysosomes come out and leak into the cytosol, the cells are undergoing apoptosis.

Also, link that to the disease called Tay-Sach. (Know a general background of this disease!!) 😉

Both the apoptosis fact---if lysosome release their contents in cell

and

lysosome pH alone will not work in cytosol are true.

I have see the second one in Cliffs too and the first one i have seen in many places as a question and answer was apoptosis.

I guess it depends on how your question will be worded.