Depends on the level of the anatomy.
If it's like legit upper level mammalian or comparative anatomy--that's an insanely difficult class.
I took took Comparative Anatomy with Biochem 2 and Physical Chemistry--netted 2 B's out of the deal, but it was my 2nd semester of my senior year with med school acceptance in hand. I perhaps could have gotten there with more motivation, butttt
Physiology is a much easier class to fit with other hard classes, IMO.