I've done numerous DITY moves, because the Army consistently gave me orders less than a month out and trans was booked out way longer than that.
First DITY was just a Uhaul as a single guy. Second, I was married with kiddo #1 and owned a house. We don't live like spartans, but we deffinetly aren't the Jones'. We used the larger sized POD and then a small Uhaul trailer for the rest of our stuff that didn't fit. Third DITY was Bragg to Texas. Had 2 kids this time. Still used 1 large POD, but had to rent a large Uhaul as well. 2 PODs would have been nice.
Cons - Biggest complaint is cost. I have paid out of pocket each move because what I can pack into a POD/Uhaul doesn't cover the rental cost. Other minor gripe is the time it takes to pack everything up. Luckily my wife was super proactive and started saving boxes 6 months out and started packing stuff away 2 months out. Any other boxes I needed I got at Lowes. Packing the POD sucks, depending on what items you have (washer/dryer/fridge/furniture) you may need friends to help move (and think about once you get there). I have moved transmissions, short blocks, washers, and dryers. For the car stuff, I made wooden boxes inside the POD and ratchet strapped them down, then filled up the empty space with random garage stuff. I did basically the same thing for the washer and dryer, made a framed box for them so that I could stack items on top of them.
Pros - you pack everything yourself, so it's probably not going to break during packing and trans. It's also a good way to purge useless stuff since your putting a hand on everything you own. On the back end you'll get it much sooner too.