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Was going to PM him but I think this is a beneficial for anyone interested.
@Raryn - what is the normal serum TSH for young otherwise healthy people?
Based on reading UpToDate, Harrison's and a few endocrinology texts, I haven't found a definitive answer. However, I did recently read this from the ATA/AACE Guidelines:
https://www.aace.com/files/hypothyroidism_guidelines.pdf
@Raryn - what is the normal serum TSH for young otherwise healthy people?
Based on reading UpToDate, Harrison's and a few endocrinology texts, I haven't found a definitive answer. However, I did recently read this from the ATA/AACE Guidelines:
https://www.aace.com/files/hypothyroidism_guidelines.pdf
^ So in an otherwise healthy 30 year old female or heck even 20 or 25 year old with a few vague symptoms that may or may not be related to PH, what do you do with a TSH of 4.0 mIU/L?The National Academy of Clinical Biochemists, however, indicated that 95% of individuals without evidence of thyroid disease have TSH concentrations below 2.5 mIU/L (85), and it has been suggested that the upper limit of the TSH reference range be lowered to 2.5 mIU/L (86). While many patients with TSH concentrations in this range do not develop hypothyroidism, those patients with AITD are much more likely to develop hypothyroidism, either subclinical or overt (87) (see Therapeutic endpoints in the treatment of hypothyroidism for further discussion).
In individuals without serologic evidence of AITD, TSH values above 3.0 mIU/L occur with increasing frequency with age, with elderly (>80 years of age) individuals having a 23.9% prevalence of TSH values between 2.5 and 4.5 mIU/L, and a 12% prevalence of TSH concentrations above 4.5 mIU/L (88). Thus, very mild TSH elevations in older individuals may not reflect subclinical ATA/AACE Guidelines for Hypothyroidism in Adults, Endocr Pract. 2012;18(No. 6) e13 thyroid dysfunction, but rather be a normal manifestation of aging. The caveat is that while the normal TSH reference range—particularly for some subpopulations—may need to be narrowed (85,86), the normal reference range may widen with increasing age (84).