NSAIDS and Asthma Help!!!

[coreytayloris]

---

Members don't see this ad.

via what mechanism nsaids exacerbate asthma? (nsaids and beta blockers contraindicated in asthma patients cause they exacerbate it)
I mean nsaids inhibit cox, thus inhibiting leukotrienes and prostaglandins synthesis...
Leukotrienes and prostaglandins are involved in asthma and inflammation so one would surely deduce that NSAIDS would help treat asthma....!!!??!
Am I missing something!?

 

[username456789]

via what mechanism nsaids exacerbate asthma? (nsaids and beta blockers contraindicated in asthma patients cause they exacerbate it)
I mean nsaids inhibit cox, thus inhibiting leukotrienes and prostaglandins synthesis...
Leukotrienes and prostaglandins are involved in asthma and inflammation so one would surely deduce that NSAIDS would help treat asthma....!!!??!
Am I missing something!?

Inhibiting COX inhibits PG synthesis, but does not inhibit LT synthesis. In fact, it shunts arachadonic acid TOWARDS forming more leukotrienes.

 

[username456789]

This basic diagram should help too:

 

[dr zaius]

Blocking COX-2 can push arachidonic acid down the leukotriene pathway, which will exacerbate asthma.

b2 adrenergic receptors in bronchi cause broncho dilation when stimulated. Beta blockers can block that receptor.

 

[robu058]

The answer to this question must have been fresh in everyone f/r/e/a/k/i/n/g mind..lol..cuz within 5 min, they overkill this..lol...me coming to pound on this some more only to realize that we are beating a dead horse..lol..

 

[OveractiveBrain]

The answer to this question must have been fresh in everyone f/r/e/a/k/i/n/g mind..lol..cuz within 5 min, they overkill this..lol...me coming to pound on this some more only to realize that we are beating a dead horse..lol..

Beating a dead horse with another dead horse?

 

[coreytayloris]

Thanks to all!!

SDN forum members are the cream of the crop no doubt!

Cheers guys!