Good luck with your decision. I am going to be attending OSU and I think it is my best option. If I was not IS and so close to OSU, though, I don't think it would be the choice I'd make. Really depends on what you like. I am from a small town and went to a small school (max. people I've been in class with at one time is 30, even for gen. ed requirements), so the thought of living in a big city and having 160 people in my class is like 😱. I'll adjust though and it's not like it's 160 people in this class and then a different 160 in another class, we're all gonna know eachother no matter if you have 80 people in your class or 160.
I too got the feeling from our facebook group that there are several people going in who already know eachother. I think a good chunk of our class either went to OSU or Findley for undergrad. There are plenty of opportunities to get to know people if you don't though. Our little get together with Three Legged cat, OH bunny girl, and myself helped me a lot. I at least know two of my future classmates who are both awesome! There will be more in August too, once we're all down in Columbus. Plus at orientation we'll be in smaller groups to get to know our classmates, so I think by day one, if you put forth any effort at all, you'll feel like you know people and aren't "alone".
For me, I like that OSU is just 3 hours from home, I can get in the car and head home after a rough week if I want to. Plus, since I'm IS its one of my cheapest options.
Also, I am a wildlife rehabber and if you are into wildlife at all, something to consider is that the Ohio Wildlife center is just 15 minutes from campus and is AWESOME! I know several people who work/volunteer there and have visited and love it. Knowing there will be somewhere I can go in the fall and spring when I just need to hold, feed, and pittle a pinkie squirrel, baby possum, or a baby bunny (if you're not a rehabber that will probably sound crazy too you 😳) is awesome. Aside from Cornell, Michigan, and Tufts, who have wildlife stuff right on campus (if the OOS costs weren't so high, I would have loved to apply to them) I think OSU is an awesome choice for wildlife lovers. Plus we got the wilds, which I've heard is an awesome sanctuary for exotic wildlife (like rhino, zebra, etc.).
Sorry, I really don't know much about Missouri so can't really comment much on it, but those are my thoughts on OSU.
And Nordicat, I know you didn't choose Ohio and a little bummed we won't be classmates, but glad you made a choice and are happy with it 👍. I hope you love Missouri.