Separate names with a comma.
Interview Feedback: Visit Interview Feedback to view and submit interview information.
Interviewing Masterclass: Free masterclass on interviewing from SDN and Medical College of Georgia
Discussion in 'Pre-Medical - MD' started by yalla22, Apr 27, 2004.
what happens when you add a strong nucleophile (R2-N-H) under ACIDIC conditions to an aldehyde?
Under acidic conditions, an amine is not a strong nucleophile, since it will be protonated and have no lone pair to go shopping for positive charge.
On the other hand, under less acidic conditions (pH 4.7), primary amines can react with carbonyls to form imines: H2N-Z + CHO -> RC=N-Z + H2O, which can then be reduced to the secondary amine.