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Discussion in 'Pre-Medical - MD' started by yalla22, Apr 27, 2004.

  1. yalla22

    yalla22 Senior Member
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    what happens when you add a strong nucleophile (R2-N-H) under ACIDIC conditions to an aldehyde?
     
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  3. liverotcod

    liverotcod Lieutenant Crunch
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    Under acidic conditions, an amine is not a strong nucleophile, since it will be protonated and have no lone pair to go shopping for positive charge.
     
  4. liverotcod

    liverotcod Lieutenant Crunch
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    On the other hand, under less acidic conditions (pH 4.7), primary amines can react with carbonyls to form imines: H2N-Z + CHO -> RC=N-Z + H2O, which can then be reduced to the secondary amine.
     

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