Orgo Question

[n2o*]

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What is the difference between a strong base and a strong nucleophile.

E2 is favored by strong bases, while SN2 is favored by strong nucleophiles.

 

[SMC2UCLA2_]

What is the difference between a strong base and a strong nucleophile.

E2 is favored by strong bases, while SN2 is favored by strong nucleophiles.

A strong nucleophile is F, Cl, Br, I in order of decreasing nucleophilicity. A strong nucleophile nucleophile is generally the anion of a monoprotic acid.

A strong base would rather extract a Hydrogen than perform a substitution reaction. This is why a strong base prefers to extract the hydorgen in an E2 reaction.

If you remember the following, you should do fine: Strong Base has OH or O-, strong nucleophile is F, Cl, Br, I.

I think that is a sufficient explanation that works for me