Pedigree Analysis

[EthioRx]

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Can someone enlighten me on Pedigree Analysis...
- How to differentiate between these four..
a) Autosomal Dominant
b) Autosomal Recessive
c) X-linked Dominant
d) X-linked Recessive

Thanks in advance....

 

[ffpickle]

Can someone enlighten me on Pedigree Analysis...
- How to differentiate between these four..
a) Autosomal Dominant
b) Autosomal Recessive
c) X-linked Dominant
d) X-linked Recessive

Thanks in advance....

First see if it is X-linked or autosomal. If it appears only in males, it is X-linked. If it is in both males and females, then autosomal.

I don't have a formal way of determining whether it is a recessive or dominant disorder. But suffice it to say that if it appears in every generation, we're talking about dominant. If it skips some generations, then it is probably a recessive disorder (or if there is a kid with the disease even those both his/her parents don't have it).

DOes this make sense?