pharm ? regarding methotrexate

Discussion in 'Step I' started by patuit79, May 24, 2006.

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  1. patuit79

    patuit79 Junior Member

    Apr 14, 2004
    A 42 year old woman has dizziness and ringing in her ears 7 days after starting a drug. Which is the cause?
    A) acetominophen
    B) aspirin
    C) auranofin
    D) methotrexate
    E) prednisone

    I chose mxt but not sure about it causing that side effect. does anyone know the answer?
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  3. darice

    darice Member 5+ Year Member

    Apr 2, 2006
    I believe those are common side effects of acetominophen....
  4. jameslynton

    jameslynton 2+ Year Member

    Apr 4, 2006
    Methotrexate - used in chemo therapy in cancer along with some of the other drugs does cause hearing loss but does not cause tinninus. Methotrexate is also used to slow long nerve damage in MS in slow progressive cases. So you will see hearing loss there also - the key is to the correct agent in the question is 8 days. Methotrexate does not cause red blood cell loss for at least two weeks after use - if I remember correctly. Normally the RBC loss translates as being tired.
  5. Idiopathic

    Idiopathic Newly Minted Lifetime Donor 10+ Year Member

    Apr 21, 2003
    Here can this not be aspirin? Tinnitus is one of the first signs of ASA intoxication. SO many drugs cause dizziness and ringing, but its classically associated with ASA toxicity.
  6. TIMMY

    TIMMY I search after truth.... 7+ Year Member

    Oct 8, 2003
    Bethesda Maryland
    I agree...I dont know if it was Goljan that drilled this point home but I remember someone constanly saying the first classical symptom of ASA tox was Tinnitus....then the other stuff like respiratory alkalosis and metabloic acidosis (Both in adults and Kids more susceptible to MA )follow.
  7. woowoo

    woowoo Member 7+ Year Member

    Aug 27, 2003
    aspirin it is. MTX's main toxicities are myelosuppression (relieved by leucovorin, and fatty liver.
  8. Idiopathic

    Idiopathic Newly Minted Lifetime Donor 10+ Year Member

    Apr 21, 2003
    Come on guys, this ones a gimme.
  9. surgwannabe

    surgwannabe Junior Member 5+ Year Member

    Dec 8, 2005
    AGREE! Just for your info, triad for the ASA overdose: fever, tinnitus, and initial respiratory alkalosis
  10. OSUdoc08

    OSUdoc08 Banned Banned

    Sep 30, 2003
    Yeah, it was Goljan.

    It's obviously ASA.

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