1) Funding (at least 1 active R01 that was recently approved)
2) Has PI trained MD/PhDs in the past and gotten them out of lab quickly? If not, does PI understand the unique time pressures on MD/PhDs and support that?
3) Is PI going anywhere?
4) Does the PI and the people in the lab seem cool?
5) Are you at all interested in the work going on there?
If all of those are favorable, it's worth a rotation.
High profile publications are a double-edged sword. If they only publish in high end journals it could mean only high risk projects. It could also mean that they refuse to publish in lesser journals which could really screw you over if your data doesn't turn out to be amazing. Keep in mind your goal as an MD/PhD student--publish at least once in a field journal or better and get graduated from the program in 7-8 years.