I have a patient with polycystic ovary syndrome (PCOS) .Now is the 4th year of her disease .She have menstrual irregularities , increasing dimension and number of follicules on echography , elevating testosterone level . She has been treated with oestrogens ( 1year ), metformine ( 2g/day for 1year )but have not much progression . Please help me to answer this : causes , complications , prognosis and treatment of this syndrome ! She's a doctor and she is very anxious actually ! Thanks a lot for your advices !