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The 2026-2027 DO School Specific Threads are now available in the School Specific Discussions forum. The 2025-2026 discussions are now available in the prior year discussions forum.
It depends too much on your schools grading schema.
Conceptually, I don't think organic is that difficult compared to say calculus based physics. However, at my school the class avg in organic was in the D+/C- range for a semester with sometimes no As on entire exams with no curve, for example. Hence, orgo was harder because of the grading, but intellectually I thought physics was more difficult and pushed me way harder intellectually even though I got relatively easy As compared to the chem department.
Hardest class for me was Honors Bio 2. No joke. The first day, the prof raised the book up and said, how many of you studied this in your AP class in high school? Everyone but me and the guy next to me raised their hand. He said "Ok, I'll just assume you know that book's material, then, and we'll move on."
I hadn't taken AP bio. God that class was hard. Got a 4.0 still, though! 👍
I didn't find ochem to be inherently more difficult than gchem or bio. It was basically a "Lego" course. Just learn how pieces fit together and know their properties.