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Primary biliary cirrhosis vs primary sclerosis cholangotis

Discussion in 'Step II' started by surgicel, Sep 27, 2014.

  1. surgicel

    surgicel 2+ Year Member

    Jul 18, 2013
    So looking at my first aid from step 1 both will have an Inc in conjugated bilirubin, but MTB says that primary biliary cirrhosis has normal bilirubin? Is this an absolute or it can be normal or elevated thing?
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  3. Apoplexy__

    Apoplexy__ Blood-and-thunder appearance 5+ Year Member

    Oct 20, 2012
    Up on the Hydra's back
    I dunno how often it would be normal, but I would definitely associate PBC with cholestasis (and therefore inc. conjugated bilirubin). I've seen UWorld questions that test this connection.
  4. Phloston

    Phloston Physician Lifetime Donor Classifieds Approved 5+ Year Member

    Jan 17, 2012
    Osaka, Japan
    My guess would be that bilirubin would actually be variable in both. It is likely that you might see increased direct (conjugated) in either.

    The giveaway is that PBC is almost always associated with high cholesterol and pruritis. PSC is usually seen with IBD and elevated ALP.

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