Primary biliary cirrhosis vs primary sclerosis cholangotis

Discussion in 'Step II' started by surgicel, 09.27.14.

  1. SDN is made possible through member donations, sponsorships, and our volunteers. Learn about SDN's nonprofit mission.
  1. surgicel

    surgicel 2+ Year Member

    Joined:
    07.18.13
    Messages:
    90
    Status:
    Medical Student
    So looking at my first aid from step 1 both will have an Inc in conjugated bilirubin, but MTB says that primary biliary cirrhosis has normal bilirubin? Is this an absolute or it can be normal or elevated thing?
     
  2. SDN Members don't see this ad. About the ads.
  3. Apoplexy__

    Apoplexy__ Blood-and-thunder appearance Bronze Donor 2+ Year Member

    Joined:
    10.20.12
    Messages:
    1,149
    Location:
    Up on the Hydra's back
    Status:
    Resident [Any Field]
    I dunno how often it would be normal, but I would definitely associate PBC with cholestasis (and therefore inc. conjugated bilirubin). I've seen UWorld questions that test this connection.
     
  4. Phloston

    Phloston Lifetime Donor 2+ Year Member

    Joined:
    01.17.12
    Messages:
    3,535
    Location:
    Osaka, Japan
    Verified
    Physician
    SDN
    Author
    My guess would be that bilirubin would actually be variable in both. It is likely that you might see increased direct (conjugated) in either.

    The giveaway is that PBC is almost always associated with high cholesterol and pruritis. PSC is usually seen with IBD and elevated ALP.
     

About the ads

Share This Page