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Alright more experienced ER/GP friends; I have a question.
The ding dong kitty in the back of my photo is Green Bean, my 3 yr old NM DSH, as mentioned above. He has allergies, we think food and environmental as it got better on the novel protein diet. He had a tough time with the transition and got quite constipated due to the fiber difference. We've managed that with miralax seemingly without issue until recently. Someone is still having constipated poops and we thought it was the other cat.
Both have had all of their vaccines and boosters since they were kittens. Olive vomited after a vaccine once and GB had some local swelling at his FVRCP site when he was one or two, otherwise handled them great. Saturday, at 3 am, he got his updated purevax rabies and FeLV vaccines. EVERYTHING on exam was normal. The thermometer came out clean. At 4:15, we heard him in the litter box and he was vocalizing (which is normal for him when he poops, I've had him worked up for FLUTD because it scare the bigeezus out of me when he was younger). He hopped out and I grabbed him to put him up on the bed. His butt touched my arm and I felt something wet, and when I looked my arm was smeared with frank blood. My first thought was "okay, maybe he was straining because he's constipated again. Or he's going into shock. Guess we gotta go find that out". Brought him back to work where his exam was normal and the vet couldn't feel any poop in his colon on palpation, and digital rectal was empty except for a LOT of blood. We couldn't tell if he was still bleeding or if he just had a large amount of blood in his fur, but a few minutes later he was cleaned up acting like nothing happened. No x-rays or bloods because he was acting normal and isn't known for eating things. Metro for 3-5 days and visbiome for the next week.
He has been fine over the weekend and appears to be pooping normally. I even checked the poop from Saturday morning and there was no blood in the litter box. Nothing on the poop that I could see, no bloody clumps of litter, nothing. If I didn't have the record of it from work I almost would have believed it was a fever dream from being awake for 22 hours straight.
Coincidence? Vaccine reaction (w/ the hypersensitivity I'm concerned this could get worse in the future)? Mercury in retrograde? Not necessarily looking for medical advice specifically since he's fine now, more just experience with reactions. I've never seen hematochezia as a standalone reaction, only secondary to anaphylaxis, of which he had none of the other symptoms.
I've had a small handful of cats present within 1-2, (one up to 24 iirc) hours post-vaccine with hematochezia - I just assumed vaccine reaction because there was no other explanation and hematochezia in general is very uncommon in cats. Never seen cats with hives, vomiting, or other reaction/anaphylaxis signs though (and that's in general, not considering vaccine reactions only). And all were completely fine within 24 hours with supportive care whether the owner chose to hospitalize them or not.Maybe. Seems a bit of a fast onset though. Can't say I've ever seen this personally.
Super uncommon in cats, but now that you're going to be a vet (techs also apply here), it's going to happen to your pet guaranteed.
Also I was going to get on my metronidazole soapbox, decided not to, but I do carry that soapbox with me at all times if you ever want me to give you my unsolicited opinions

ETA: Also have definitely had dogs in the ER that got vaccines at their GP and then got blowout diarrhea that rapidly progressed to hematochezia before the owners had even gotten home from the appointment. Doesn't always take a few hours, although in those rapid onset cases, it's usually also paired with genuine signs of full out anaphylaxis (vomiting, collapse, gallbladder wall edema +/- abdominal effusion, hemoconcentration, ELE, etc.). Anecdotally, I never saw hives with anaphylaxis, although it's absolutely supposed to be one of the possible signs. I also never saw hives progress to anaphylaxis, although that's absolutely possible too.
Saw a ton of anaphylaxis/hives when working in Florida. At least 1-2/day. Probably my favorite emergency. Some dogs left with epipen scripts on their 3rd or 4th repeat event, though (I also have an epinephrine soapbox, although it's smaller and shorter than my metro soapbox

ETA x2: Also just want to add for everyone's amusement - had a Chilean flamingo break with very acute onset, but also very quickly self resolving, hematochezia within minutes of recovering from an anesthetized exam. No real explanation for that one unless he was allergic to meloxicam, ivermectin, or Excede which he got 5-10min prior to iso being turned off. Anaphylaxis is nearly unheard of in birds so I can't even tell you if that was the cause. He was literally blowing out hematochezia for like 5-10 minutes, then was fine

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