uw question help

[deepbluesea]

Milrinone is a phosphodiesterase 3 inhibitor. Positive ionotrope. use in CHF..
which of the following is an additional pharmacological effect of this drug.
narrowed down choices to

--->Vasodilation

or

--->Sodium and Water retention



(the answer given was vasodilation - ie. due to increased CAMP levels (beta 2 agonists for instance cause vasodilation by increase in CAMP levels_

I couldn't rule out sodium/water retention though as increased CAMP levels cause increased renin release (eg. with beta 1 receptor stimulation)...

is my thinking correct that renin angiotensin system can be activated and lead to sodium/water retention this way?

Also, if that's the case, then phospodiesterase inhibitors wouldn't be a good treatment for CHF

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[Ross434]

you'll probably get a lot more results posting this in the pharmacy forum