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uw question help

Discussion in 'Medical Students - MD' started by deepbluesea, Jan 4, 2009.

  1. deepbluesea

    deepbluesea Junior Member
    5+ Year Member

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    Milrinone is a phosphodiesterase 3 inhibitor. Positive ionotrope. use in CHF..
    which of the following is an additional pharmacological effect of this drug.
    narrowed down choices to

    --->Vasodilation

    or

    --->Sodium and Water retention



    (the answer given was vasodilation - ie. due to increased CAMP levels (beta 2 agonists for instance cause vasodilation by increase in CAMP levels_

    I couldn't rule out sodium/water retention though as increased CAMP levels cause increased renin release (eg. with beta 1 receptor stimulation)...

    is my thinking correct that renin angiotensin system can be activated and lead to sodium/water retention this way?

    Also, if that's the case, then phospodiesterase inhibitors wouldn't be a good treatment for CHF
     
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  3. Ross434

    7+ Year Member

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    you'll probably get a lot more results posting this in the pharmacy forum
     

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