Well, since you asked...
1.) They read the 5th line of your 3rd AMCAS activity only. If there's a typo, you get screened out;
2.) They read the first sentence of the last paragraph of your PS. If the word "medicine" is not there, you go in the trash. Obviously your statement was way too off topic;
3.) They read only the letterheads of your LORs. If there is anyone without the title of Dr., you're gone. Content doesn't matter, it's all about titles;
4.) They read ONLY the response to their second secondary essay. Make this one the best, half ass all the others since they get glossed over;
5.) If a member of the admission committee physically raises their eyebrows at your MCAT/GPA combination, you go in the trash. Numbers don't matter, it's all about first impressions. Anything extreme in this category is detrimental;
6.) If you have an IA, automatic II. Medical schools love, love, LOVE baddies;
7.) If you were in a fraternity/sorority and mention the word "hazing" as a way you learned teamwork and sacrifice, automatic II;
8.) Finally, if you mention blue broccoli, a lady in a suit pondering the meaning of life (your life) at a desk, or a suspicious black cat, you can expect a II.
Sure up all of these things and you'll be good.