what is the function of the SH2 domain

[mj6969]

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Protein-protein interactions
Kinase activity
Binding the signal molecule
Transmembrane domain

 

[iA-MD2013]

are you kidding me?!

 

[sleepy425]

ummm, i hope you're not studying that for mcat, cuz it won't help, but SH2 domains bind phosphotyrosine residues (so IRS-1 has a SH2 domain that binds the insulin receptor's cytosolic domain once the receptor has self-phosphorylated, then PI3K binds phosphorylated IRS-1 with another SH2 domain).

 

[sleepy425]

oh, those are answer choices, i see, so it's protein-protein interactions, cuz it doesn't have kinase activity, it doesn't bind the signal molecule (that's a receptor), and it's not a transmembrane domain

 

[Vihsadas]

The MCAT forums are not for homework help.