It would be difficult to assess the difficulty of the class without knowing where you go. I can tell you that at my school the class was pretty straight forward. The lab that was associated with it was a bitch. It had two 3-plus hour labs a week. Everylab took the whole class period, and you were dealing with things on a microgram level, so you had to be extremely carefull with everystep or your yield would suck, and you'd get a bad grade.