Jan 6, 2014
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UW states that fragile X syndrome is the 2nd most common genetic cause and the most common inherited cause of mental ******ation in males. What is the difference between genetic cause and inherited cause? Aren't they the same? What are the 2nd and 3rd most common inherited cause of male mental ******ation? Thanks!
 

Reperfused

2+ Year Member
Aug 24, 2015
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Medical Student
Nope they're not the same.
Genetic can be either inherited or not inherited. A problem in your genes = genetic cause. A problem in your genes that you got from your father or mother = inherited, e.g. you got a mutated gene from your mother/father for hemophilia. On the other hand, a problem in your chromosomes e.g. Down syndrome, is not inherited (although it is a genetic disease), it's not something you got from your father/mother, it's unique in you, arising at the time of fertilization.

Down syndrome is the most common genetic cause of mental ******ation.
2nd is Fragile X as you stated.

Hope that makes sense.
 
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Jun 30, 2015
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Zurich, Switzerland
Hi and thanks for the explanation

Just as a side note: Down Syndrome may be inherited from a parent with a balanced robertsonian translocation (where a carrier parent typically has a fusion of the long arms of chromosomes 14 and 21).
 
May 27, 2015
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Hi and thanks for the explanation

Just as a side note: Down Syndrome may be inherited from a parent with a balanced robertsonian translocation (where a carrier parent typically has a fusion of the long arms of chromosomes 14 and 21).
True. The translocation form of Down syndrome is very rare (only 4% I guess). So, overall, Fragile X surpasses it comfortably.
Another side note: when you have a 'fragile' X, your Y dominates (macroorchidism)
 
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