Get help with your application

Use all the free resources available to you from SDN: articles, guides, expert advising, forums discussions, and school research.

Actin11

Full Member
7+ Year Member
Hello everyone,

Quick Q about the E1 vs E2 products, would appreciate some clarification!

Do E1 and E2 products both use Zaitsev's rule to form the "most substituted" product?

I am a bit confused, because I think that they do with the exception if a tertiary halide is attacked by a large, bulky nucleophile yes? This would then form the least substituted, or anti-Hofmann product, yes?

Thanks, and happy studying to you all!