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I'm surprised that this isn't taught more - my residents never understand this either.
I always use 1:1 or 1:1.5 to get more volume for less pressure in patients without lung disease.
I've never seen an upsloping CO2 curve in a normal-lung patient I don't think.
My bet is it has to do with medical schools' basic teaching of ventilation. It's oversimplified to PEEP/FiO2 for oxygenation and Vt/RR for ventilation. Anatomic shunting, dead space and V/Q mismatch are "theoretical" concepts that most medical schools do a terrible job of explaining. Heck, most physicians don't truly understand them.
That's interesting. This is something I realized on my own in a round about sense. I think most people should noticed that you decrease the I:E ratio to 1:2.5 or 1:3, the peak pressures increase (which in my head made sense, since you are trying to shove the same amount of air in a shorter period of time; similar to how much force you need to apply to a syringe to administer meds fast vs slow). I had a different patient with normal lungs one day, who had slightly elevated peak pressures, when I thought of the first point, I increased the I:E ratio and fixed that problem.