Feline hypertrophic cardiomyopathy

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Tigerz_Fan

also known as Towanda!!!
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Hello all,

I am a visitor to your forum as a 3rd year medicine resident. I am trying to find information regarding the use of Plavix +/- ASA to prevent thromboembolic disease in cats diagnosed with hypertrophic cardiomyopathy. As an MD, not DVM, my university library doesn't allow access to vet journals. Google search is painful. Can anyone tell me a published study that shows Plavix is superior to ASA in a case such as this.

FYI-this is not a bid for medical advice, just looking for evidence-based medicine, article, and/or so I can make my own informed decision.

Thank you!

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There are no data on primary prevention of aortic embolism in cats with HCM. There is an ongoing study comparing aspirin to Plavix for prevention of further episodes in cats that have already suffered a cardiogenic emboli. They're still enrolling cases so final results aren't out yet.
 
Thank you! 😀
 
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I just wanted to comment, because I believe it was at least partially (or mainly?) due to Plavix therapy that my cat lived for almost a month after a saddle thrombus episode. He was treated by a team that included a vet cardiologist, and I was able to take him home after the initial few days, on Plavix.

Within two weeks, he was using the leg again, and by three weeks, he was almost normal (gait).

We stopped the Plavix in anticipation of a thoracic surgery, and the morning of surgery, he suffered another thrombo-emboli, and then a second episode (suspected clot to the brain... seizure..) and he was euthanized.

His echo did show some mild HCM at the time.

(His final diagnosis upon necropsy was bronchiolar-alveolar carcinoma, high grade with cardiac and nodal mets. 🙁 (The mets were not visible on chest rads, only a solitary mass). )
 
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I just wanted to comment, because I believe it was at least partially (or mainly?) due to Plavix therapy that my cat lived for almost a month after a saddle thrombus episode. He was treated by a team that included a vet cardiologist, and I was able to take him home after the initial few days, on Plavix.

Within two weeks, he was using the leg again, and by three weeks, he was almost normal (gait).

We stopped the Plavix in anticipation of a thoracic surgery, and the morning of surgery, he suffered another thrombo-emboli, and then a second episode (suspected clot to the brain... seizure..) and he was euthanized.

His echo did show some mild HCM at the time.

(His final diagnosis upon necropsy was bronchiolar-alveolar carcinoma, high grade with cardiac and nodal mets. 🙁 (The mets were not visible on chest rads, only a solitary mass). )

Sorry to hear of your loss 🙁, thank you very much for your story.
 
CookieBear I'm so sorry to hear about your kitty. 🙁 How bad was the saddle thrombus episode? I'm curious because we usually euthanize when a cat comes in with this so I wasn't aware there might be other medical options. Aside from the plavix did they use anything else (ie: pain meds) after the episode? I'm sorry it didn't give you more time with her but that's great to hear that you at least got some extra time.
 
Thank you, Tigerz. He was a sweet cat. We miss him.

Cat, thank you. I owe that month with Sonny to the 24-hour referral practice that I took him to immediately. We apparently found Sonny within just a few hours of the episode (probably within 2-3 hours max. of the thrombus), and I had him at the hospital within another hour, tops. It was predominantly one rear leg that was lame. I can't remember if it was cool to the touch already; I think I still remember his toes being pink, but that might be my recollection later.

I don't know all details, but from what I recall, the admitting doc started him on pain meds right away, fluids, I'm sure other stuff too, and they kept him for 3-4? days. The following day, the cardiologist was in, and I know they were monitoring electrolytes. Ironically, we had just found the presumed-solitary lung mass just two? days prior at my own clinic, and had a full panel of bloods too, not to mention a BP - all findings had been fine except for that mass.

The month doesn't seem like alot, but prior to the exam/bloods/rads, Sonny was doing great. My husband noted that he was just acting a bit 'off' - but was still eating, etc. Ten year old cat... no prior history of anything bad, and he was seen yearly or even twice yearly. So I went from having what I thought was a healthy cat, to "lung mass" - and then, surprise, saddle thrombus but days later.. and this was just months after I got my KSU acceptance letter.

I think the key factor in getting him past the initial thrombus was that I found him quick, and got him there quick. The hospital has multiple specialists and all the great 'toys', great staff, etc. He was lucky in that his medical management got him through the episode. I know that in many cases these cats do not regain perfusion of the leg, or kick out more clots/emboli, etc.

I think I had Sonny back there twice for rechecks, and in-anticipation/hopes of removing the lung mass. The cardiologist was amazed at how well he was walking 2 weeks later. In hind-sight, I probably wouldn't pursue a chest surgery now, if presented with the same scenario again - but it's hard to put everything in perspective when your cat isn't terribly old, was previously great, and the general consensus/ideal was that it was just one lone mass. I know a CT would've shown the nodules that the rads didn't, but I was willing to skip the CT and let them cut him, once we got past the thrombus. Unfortunately it was not to be so 'simple'.

It will be two years next month since we lost him, and I still miss him. I have his brother littermate still - from when they were tiny, and the two were inseparable.
 
CookieBear I'm so sorry to hear about your kitty. 🙁 How bad was the saddle thrombus episode? I'm curious because we usually euthanize when a cat comes in with this so I wasn't aware there might be other medical options. Aside from the plavix did they use anything else (ie: pain meds) after the episode? I'm sorry it didn't give you more time with her but that's great to hear that you at least got some extra time.

I believe one of the better current options for medical treatment is streptokinase. Problem is its expensive. I know the medium size 24 hour hospital I work at doesn't carry it. If the patients are looking to treat we usually immediately refer them to Tufts.
 
The results of streptokinase in these cats has been disappointing and in general are no better than just supportive care. For thrombolysis, tPA is effective but the side effects are a big problem, mostly bleeding and reperfusion injury. About half die from complications and the other half rethrombose pretty soon.

Catheter angioplasty has also been tried but you still have the same issues with reperfusion, especially hyperkalemia.

The problem is a lot more complicated than just obstruction of flow in the aorta. In fact you can go in and ligate the distal aorta in a cat and nothing at all happens. Also you have the underlying heart disease to deal with.
 
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