Originally posted by trypmo
I think the dental caries vaccine thingy refers to injecting something to modify (genetically, I think?) the salivary glands such that they would produce an agent antagonistic to bacterial growth and/or adhesion. Apparently, the bacteria secrete their own adhesion proteins and use them to attach to the surface of the teeth, and I think this is what they were primarily fighting against.
In any case, from what I've read, it's a long way from being implemented in humans. I'll go poke around and see whether I can find that reference for y'all. If anyone's particularly interested in the reference, give me a shout and I'll go actively looking (otherwise I'll probably forget).
*** EDIT: Looks like I actually saved the references in a non-inaccessible directory! I'm sure I read about the actual vaccine online, so I really would have to go digging for that, but these should give you some idea of what they're trying to do.
Glushka, J. et al. "Complete Structure of the Adhesin Receptor Polysaccharide of Streptococcus oralis ATCC 55229 (Streptococcus sanguis HI)" Biochemistry 31: 10741 (1992).
Engels-Deutsch, M. et al. "Insertional Inactivation of pac and rmlB Genes Reduces the Release of Tumor Necrosis Factor Alpha, Interleukin-6, and Interleukin-8 Induced by Streptococcus mutans in Monocytic, Dental Pulp, and Periodontal Ligament Cells." Infection and Immunity 71: 5169 (2003).
HAJISHENGALLIS, G. et al. "Inhibition of Streptococcus mutans Adherence to Saliva-Coated Hydroxyapatite by Human Secretory Immunoglobulin A (S-IgA) Antibodies to Cell Surface Protein Antigen I/II: Reversal by IgAl Protease Cleavage." Infection and Immunity 60: 5057 (1992).
PM me if you'd like me to email one or more of these to you in PDF format.
HTH