- Joined
- Jul 30, 2002
- Messages
- 892
- Reaction score
- 3
So, there are a couple of erratas i found, and some may need some clarification. Feel free to chime in.
1. In the phsyiology of B12 transport from the mouth. From what I understand that B12 exogenously is bound to a protein which is cleaved by pepsin in the stomach and it is there where it binds R-binder protein (which is then taken to the duodenum for cleavage by pancr enz to bind to IF)According to Dr. G, B12 binds to the R protein in the saliva to protect being destoryed by the acid in the stomach. After that, the path he describes is the same. I amnot sure.
2. Also, in B12 deficiency--the folate you give to overcome the anemia exogenously is in THF form? It would have to be, rite? But, then again I thought all folate taken in exogenously is in the N5 THF form?
3. According to BRS, you only get increased levels of HgB F in the MAJOR form of Beta thal. And increased levels of hgBA2 in MINOR Beta thal. Wouldn't you get increased levels of both in both forms, just to a varying degree?
4. Also, I don't understand--in BRS it says, in alpha thal, you have barts HgB in fetal life and HgH in adult life. I thought that those just dependent on the amount of gene deletions u had (3 gene del would produce HgH and 4 would produce Barts). Can anyone explain?
Thanks a lot.
1. In the phsyiology of B12 transport from the mouth. From what I understand that B12 exogenously is bound to a protein which is cleaved by pepsin in the stomach and it is there where it binds R-binder protein (which is then taken to the duodenum for cleavage by pancr enz to bind to IF)According to Dr. G, B12 binds to the R protein in the saliva to protect being destoryed by the acid in the stomach. After that, the path he describes is the same. I amnot sure.
2. Also, in B12 deficiency--the folate you give to overcome the anemia exogenously is in THF form? It would have to be, rite? But, then again I thought all folate taken in exogenously is in the N5 THF form?
3. According to BRS, you only get increased levels of HgB F in the MAJOR form of Beta thal. And increased levels of hgBA2 in MINOR Beta thal. Wouldn't you get increased levels of both in both forms, just to a varying degree?
4. Also, I don't understand--in BRS it says, in alpha thal, you have barts HgB in fetal life and HgH in adult life. I thought that those just dependent on the amount of gene deletions u had (3 gene del would produce HgH and 4 would produce Barts). Can anyone explain?
Thanks a lot.