Starkville is basically a small college town. My biggest adjustment has been getting used to not having a lot of options in terms of stores and resources. Sure there's a Lowe's hardware, two grocery stores, and a Walmart, but I was really used to being able to visit five different places to find what I wanted. I miss Target most of all. Starkville has mostly everything you need for day to day, some cute shops on a cute little downtown Main St, a few fun restaurants, a small but (undergrad-)thriving nightlife. We've even got some fun musicians through in the past few weeks and coming months, including Snoop Dogg, OAR, and Citizen Cope, although big names are far and few.
When I interviewed here, I immediately HATED Starkville. I had never before set foot in Mississippi, and the isolation and humid winter weather made me uneasy. Then I interviewed, and fell in love with the school. I chose MSU over my other option purely because I loved the school, not the town. Since that point, I have adjusted quite a bit and am now fond (most of the time) of the little town as well.
The two good parts about Starkville are SUPER CHEAP housing costs, and lack of stuff to do therefore you study! We bought an adorable house with a huge backyard for about half of what we would have paid back home, and I absolutely love it.
The weather is unbearably hot in the summer. For me, I'm going back home during the middle of the summer so I don't get too sick of the place before I head into my second year. The cold part of winter only lasted a few short weeks, and it's generally really rainy, but spring seems to have started already (yesterday).
The people are generally very pleasant, and people get really excited about MSU sports games. The closest mall that even remotely compares to the malls you are used to is an hour north in Tupelo, and the closest Target is an hour and a half east in Tuskaloosa, AL.
Since half the vet class will be out-of-state, you'll have people to sympathize with you as you adjust to the south, especially Starkville. The other half will likely be from MSU's undergrad, or somewhere fairly local, and they are always more than happy to help you find your way around to whatever you need.