PGE1 vs PGE2

[med217]

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Pg 356 FA2016 says NSAIDs decrease PGE2 --> decrease gastric mucosa protection

We know misoprostol (PGE1 analog) is used to counteract NSAID mucosal impairment. Is it PGE1 or PGE2 that maintains healthy mucosa?

 

[das0088]

cox1 for healthy mucosa and cox2 for inflammation

PGE1 for decrease vascular tone and keeping PDA open
PGE2 for increasing uterine tone, abortificant

 

[IMG217]

Yes, PGE2 protects gastric mucosa.
PGE2 has 4 receptors (EP1, EP2, EP3 and EP4). Misoprostol, which is a PGE1 analogue, is an EP3 agonist (EP3 inhibits gastric acid secretion and increases gastric mucus production).
(source: LWW pharmcards)