• Set Yourself Up For Success Webinar

    October 6, 2021 at 2 PM Eastern/11 AM Pacific
    SDN and Osmosis are teaming up to help you get set up for success this school year! We'll be covering study tips, healthy habits, and meeting mentors.

    Register Now!

  • Site Updates Coming Soon

    Site updates are coming next week on Monday, Wednesday, and Friday. Click the button below to learn more!

    LEARN MORE

nothisispatrick

Full Member
7+ Year Member
Apr 10, 2014
16
0
176
  1. Pre-Health (Field Undecided)
In Sketchy they say Sodium Bicarbonate is used to treat TCA overdose. One of the reasons they say is because it increases serum pH which favors the non-ionized form of the drug. Why is this? I thought increase serum pH > less H+. Then to compensate for this decrease in H+, wouldn't TCA ionize more to replace to lost H+ ions?
 
Upvote 0

DrStephenStrange

OMS-IV C/O 2022
2+ Year Member
Oct 25, 2017
3,008
4,480
126
The New York Sanctum
  1. Medical Student
Sodium bicarbonate also acts as a buffer NaHCO3/HCO3- when administered intravenously. More or less keeping the blood pH around normal level (7.35-7.45). So if the person was in acidosis due to ionized TCA (overdose) and then you give them Sodium bicarb it would raise the pH up to normal and keep it there which is probably around the same level where the drug is at its isoelectric point (neutral).
 
Last edited:
Upvote 0

Oligodinero

Full Member
2+ Year Member
May 1, 2019
367
900
116
  1. Resident [Any Field]
My understanding is sodium bicarbonate is given in TCA overdose to supply Na+ ions to counteract the Na+ blockade effects on the myocardium (manifested by a widened QRS). The bicarbonate does nothing to enhance elimination....it's all about treating the widened QRS and treating acidosis if present.
 
Upvote 0
About the Ads
This thread is more than 1 year old.

Your message may be considered spam for the following reasons:

  1. Your new thread title is very short, and likely is unhelpful.
  2. Your reply is very short and likely does not add anything to the thread.
  3. Your reply is very long and likely does not add anything to the thread.
  4. It is very likely that it does not need any further discussion and thus bumping it serves no purpose.
  5. Your message is mostly quotes or spoilers.
  6. Your reply has occurred very quickly after a previous reply and likely does not add anything to the thread.
  7. This thread is locked.